Sequence based prediction of linear autoepitopes involved in pathogenesis of IPAH and the corresponding organism sources of molecular mimicry WP1. Some important features concerning our evaluation of DQPA occurrences
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WP1. Some important features concerning our evaluation of DQPA occurrences in sequence database (i.e. SPECIES_VALENCE approach). SP_VAL is based on four important features of our evaluation. First of all, the consistent threshold of the selected DQPA represents an important parameter of specificity together with overall BLAST evaluation of DQPA similarities. Secondly, SP_VAL as propensity-related approach makes it possible to process less favorable DQPA identities evaluated as important in some cases of higher frequency. Thirdly, implemented empirical statistics of SDF and EDO values can be used even under otherwise hardly processable conditions. Fourthly, alternative models are included to better analyze different aspects of evaluated reality.
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تاریخ انتشار 2014